391 476
Table 1 – Baseline characteristics
Characteristic Mirabegron
(
n
= 1203)
Tolterodine
ER (
n
= 1561)
Darifenacin
(
n
= 126)
Fesoterodine
(
n
= 1287)
Flavoxate
(
n
= 144)
Oxybutynin
ER (
n
= 1144)
Oxybutynin
IR (
n
= 5779)
Propiverine
(
n
= 95)
Solifenacin
(
n
= 8191)
Tolterodine
IR (
n
= 1523)
Trospium
chloride
(
n
= 943)
All patients
(
N
= 21 966)
Gender,
n
(%)
Male
293 (24)
563 (36)
*37 (29)
333 (26)
68 (47)
359 (31)
1748 (30)
22 (23)
2372 (29)
440 (29)
278 (29)
6513 (30)
Female
910 (76)
998 (64)
89 (71)
954 (74)
76 (53)
785 (69)
4031 (70)
73 (77)
5819 (71)
1083 (71)
665 (71)
15483 (70)
Age, years
Mean (SD)
64.1 (14.8)
64.6 (16.1)
63.5 (14.9)
63.3 (15.8)
64.6 (16.7)
61.6 (17.5)
63.4 (17.0)
66.3 (14.3)
63.8 (16.2)
66.4 (15.2)
66.3 (15.8)
63.94 (16.3)
Range
19.0–95.0
19.0–99.0
28.0–94.0
18.0–96.0
19.0–98.0 18.0–99.0
18.0–102.0
37.0–92.0
18.0–106.0 18.0–96.0
18.0–97.0 18.0–106.0
Age group,
n
(%)
<
65 yr
542 (45)
685 (44)
60 (48)
623 (48)
68 (47)
596 (52)
2685 (46)
41 (43)
3816 (47)
615 (40)
372 (39)
10103 (46)
65 yr
661 (55)
876 (56)
66 (52)
664 (52)
76 (53)
548 (48)
3094 (54)
54 (57)
4375 (53)
908 (60)
571 (61)
11893 (54)
Treatment status,
n
(%)
Naı¨ve
476 (40)
1150 (74)
*73 (58)
799 (62)
111 (77)
907 (79)
5233 (91)
46 (48)
7021 (86)
990 (65)
549 (58)
17355 (79)
Experienced 727 (60)
411 (26)
53 (42)
488 (38)
33 (23)
237 (21)
546 (9.4)
49 (52)
1170 (14)
533 (35)
394 (42)
4641 (21)
CCI
Mean (SD)
0.38 (0.78)
0.35 (0.78)
0.41 (0.87)
0.40 (0.88)
0.47 (0.79)
0.36 (0.78)
0.38 (0.83)
0.44 (0.92)
0.38 (0.84)
0.36 (0.77)
0.38 (0.80)
0.38 (0.82)
Range
0.0–6.0
0.0–5.0
0.0–7.0
0.0–8.0
0.0–3.0
0.0–6.0
0.0–8.0
0.0–4.0
0.0–8.0
0.0–5.0
0.0–7.0
0.0–8.0
Hypertension,
n
(%)
No
1021 (85)
1316 (84)
111 (88)
1070 (83)
113 (78)
979 (86)
4865 (84)
74 (78)
6844 (84)
1270 (83)
795 (84)
18458 (84)
Yes
182 (15)
245 (16)
15 (12)
217 (17)
31 (22)
165 (14)
914 (16)
21 (22)
1347 (16)
253 (17)
148 (16)
3538 (16)
Polypharmacy,
n
(%)
0
113 (9.4)
172 (11)
*16 (13)
120 (9.3)
15 (10)
122 (11)
630 (11)
6 (6.3)
811 (9.9)
135 (8.9)
77 (8.2)
2217 (10)
1–3
329 (27)
515 (33)
36 (29)
424 (33)
28 (19)
365 (32)
1936 (34)
24 (25)
2680 (33)
484 (32)
259 (27)
7080 (32)
4–5
218 (18)
263 (17)
22 (17)
227 (18)
17 (12)
182 (16)
1055 (18)
15 (16)
1514 (18)
262 (17)
170 (18)
3945 (18)
6–8
245 (20)
321 (21)
29 (23)
253 (20)
34 (24)
215 (19)
1031 (18)
23 (24)
1612 (20)
291 (19)
213 (23)
4267 (19)
>
8
298 (25)
290 (19)
23 (18)
263 (20)
50 (35)
260 (23)
1127 (20)
27 (28)
1574 (19)
351 (23)
224 (24)
4487 (20)
CCI = Charlson comorbidity index; ER = extended release; IR = immediate release; SD = standard deviation.
*
p
<
0.05 versus mirabegron.
E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 3 8 9 – 3 9 9
391